PCSK9 and ANGPTL3 levels correlate with hyperlipidemia in HIV-lipoatrophy, are regulated by fasting and are not affected by leptin administered in physiologic or pharmacologic doses

PCSK9, ANGPTL3, and FABP4 have important roles in lipid metabolism and energy homeostasis. However, their possible role in regulating lipid metabolism in lipodystrophy and their potential interplay with leptin remains largely unknown.

In the present study, the levels of PCSK9, ANGPTL3, and FABP4 were assessed in normal subjects and subjects exhibiting HIV and HAART-induced metabolic syndrome with lipoatrophy and hypoleptinemia. Moreover, it was evaluated whether the leptin, PCSK9, ANGPTL3, and FABP4 pathways are independent of each other.

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